%0 Journal Article
%T Significance of combined detection of Cys-C, NGAL and KIM-1 in contrastinduced nephropathy after coronary angiography
%A Changyou Xuan
%A Cheng Peng
%A Feng Wang
%A Junhui Li
%A Niansong Wang
%A Qing Zhao
%J -
%D 2014
%X To evaluate the significance of combined detection of Cystatin-C (Cys-C), neutrophil gelatinase-associated lipocalin
  (NGAL) and kidney injury molecule-1 (KIM-1) in the diagnosis of contrast-induced nephropathy (CIN) after
  coronary angiography (CAG). Sixty-nine patients receiving CAG with high-risk of CIN (risk score not less than 6 or
  eGFR not more than 60ml/min) were enrolled in this study. Blood and urine samples were collected before and after
  CAG. Levels of Cys-C, NGAL and KIM-1 were determined by ELISA methods to further explore the specificity and
  sensitivity for the diagnosis of CIN. The results showed that maximum levels of serum Cys-C (r= 0.798£¬P<0.001),
  urine NGAL (r= 0.320, P = 0.007) and urine KIM-1(r= 0.418£¬P<0.001) post-CAG were positively correlated with
  the maximum levels of serum creatinine (SCr) post-CAG. The levels of Cys-C at 24h post-CAG (r= 0.840), NGAL at
  3h post-CAG (r= 0.367) and KIM-1 (r= 0.458) at 12h post-CAG correlated with maximum SCr post-CAG most
  significantly. The changes of NGAL£¨r= 0.271, P = 0.020£©and KIM-1£¨r= 0.230, P = 0.049£©were positively
  correlated with the changes of SCr while Cys-C not. For the diagnosis of CIN, the specificity, sensitivity and AUC of
  NGAL were 93.9%, 66.7% and 0.659 while the specificity, sensitivity and AUC of KIM-1 were 95.2%, 75% and
  0.742 respectively. In conclusion, NGAL and KIM-1 were valuable for CIN diagnosis after CAG. NGAL can indicate
  the diagnosis of CIN at 3 hours after CAG, while KIM-1 can indicate CIN at 12 hours after CAG more sensitively.
%K contrast-induced nephropathy
%K acute kidney injury
%K coronary angiography
%K Cystatin C
%K neutrophil gelatinase-associated lipocalin
%K kidney injury molecule-1
%K list of open access journals
%K open access
%K open access journals
%K open access publication
%K open access publisher
%K open access publishing
%K open access journal articles
%K imedpub
%K imedpub publishing
%K insight medical publishing
%K imedpub online
%U https://www.imedpub.com/articles/significance-of-combined-detection-of-cysc-ngal-and-kim1-in-contrastinduced-nephropathy-after-coronary-angiography.php?aid=15452