%0 Journal Article
%T Richtera£¿£¿s Syndrome as an Ocular Manifestation of Systemic Disease in a Dog: A Case Report
%A Chris M Reilly
%A Erika P Berger
%A Gil Ben-Shlomo
%A Lionel Sebbag
%A Margaret L Musser
%A Rachel A Allbaugh
%A Rita F Wehrman
%J -
%D 2019
%X This report documents the progression of chronic lymphocytic leukemia into diffuse aggressive lymphoma, or Richter¡¯s syndrome, first manifesting as unilateral ophthalmic disease in a 10-year-old coonhound. Following a 1.5-year course of chronic leukemia that was in a clinical remission, the dog was presented for a protruded left globe. Orbital ultrasound revealed a vascular mass located ventromedially and causing indentation of the sclera. Skull computed tomography showed exophthalmos due to a soft tissue mass and concurrent left mandibular bony lysis. Abdominal ultrasound and computed tomography revealed a large right adrenal mass, peritoneal lymphadenopathy, multiple liver nodules, kidney infarcts, and dorsal body wall nodules. A diagnosis of uveal lymphoma with scleral extension was obtained on histopathology after surgical removal of the affected eye. Cancerous cells were large with high-grade proliferative features, consistent with T-cell lymphoma based on immunophenotyping (CD3+/CD20-). The dog was euthanized 2 days postoperatively due to declining systemic condition. Richter¡¯s syndrome is a rare condition, but generally carries a grave prognosis. To the authors¡¯ knowledge, this is the first report of Richter¡¯s syndrome in a veterinary patient presenting with an ophthalmic manifestation.
%K Ocular Manifestation
%K Richter's syndrome
%K list of open access journals
%K open access
%K open access journals
%K open access publication
%K open access publisher
%K open access publishing
%K open access journal articles
%K imedpub
%K imedpub publishing
%K insight medical publishing
%K imedpub online
%U https://www.imedpub.com/articles/richters-syndrome-as-an-ocular-manifestation-of-systemic-disease-in-a-dog-a-case-report.php?aid=24123