%0 Journal Article
%T Prognostic and clinicopathologic significance of long non-coding RNA opa-interacting protein 5-antisense RNA 1 in multiple human cancers
%A Chao Tu
%A Chenghao Zhang
%A Jieyu He
%A Lin Qi
%A Shuangqing Li
%A Wanchun Wang
%A Xiaolei Ren
%A Zhihong Li
%A Zhixi Duan
%J Artificial Cells, Nanomedicine, and Biotechnology
%D 2020
%R https://doi.org/10.1080/21691401.2019.1709854
%X Abstract Background: OIP5-AS1 has been reported to be aberrantly expressed in multiple cancers and associated with clinical outcomes. We conducted this study to assess the generalized prognostic value of OIP5-AS1 in cancers. Methods: PubMed, Web of science, and Cochrane Library were searched for eligible studies. Hazards ratios (HRs) or odd ratios (ORs) with 95% confidence intervals (CIs) were pooled to estimate the prognostic value of OIP5-AS1 in cancers, including overall survival (OS), age, gender, tumor size, clinical stage, and lymph node metastasis (LNM). Publication bias was measured by Begg¡¯s test and funnel plot. Sensitivity analysis were used to detect the stability of pooled results. Results: Overall, eleven studies containing 713 patients were eventually enrolled. The pooled results showed that high OIP5-AS1 expression was correlated with shorter OS (HR£¿=£¿0.48, 95%CI: 0.35¨C0.64), regardless of the sample size, tumor type and follow-up time. Furthermore, elevated expression of OIP5-AS1 indicated advanced clinical stage (OR£¿=£¿2.12, 95% CI: 1.06¨C4.23), but not associated with age, gender, tumor size and LNM. No publication bias was detected. Conclusion: High expression of lncRNA OIP5-AS1 may predict a poor OS and advanced clinical stage, implicating that OIP5-AS1 may be a possible prognostic factor in cancers
%U https://www.tandfonline.com/doi/full/10.1080/21691401.2019.1709854