%0 Journal Article
%T 体质量指数对2型糖尿病行冠状动脉旁路移植术患者预后的影响
%A 刘孝洁　李田军　王丽娟　王苏德娜　于洋　敖虎山
%J -
%D 2019
%R 10.13362/j.jpmed.201906003
%X 摘要 目的　探讨不同体质量指数（BMI）对2型糖尿病行冠状动脉旁路移植术（CABG）患者预后的影响。 方法　收集2003年1月1日—2009年12月31日在中国医学院科学院&北京协和医学院阜外医院行CABG的771例2型糖尿病患者的临床资料。按中国BMI标准分为正常体质量组、超重组、肥胖组。主要终点是心房颤动、神经并发症、肾功能衰竭、感染、重症监护室（ICU）停留时间、机械通气时间和出血量等围术期各项结局和长期（5年）的主要心脑血管事件（MACCEs），主要包括全因死亡、心肌梗死、心力衰竭、脑梗死或需要血运重建等指标。统计学方法主要采用单因素和多因素Logistic、多元线性回归和Cox回归分析。 结果　Logistic回归分析和多元线性回归分析显示,超重组和肥胖组患者心房颤动、神经并发症、肾功能衰竭、感染、ICU停留时间、机械通气时间、出血量等方面与正常体质量组相比，差异无统计学意义(P＞0.05)。Cox回归分析5年随访数据发现，超重组和肥胖组患者长期MACCEs与正常体质量组相比，差异无统计学意义(P＞0.05)。 结论　BMI对接受CABG治疗的2型糖尿病患者预后无明显影响。<br>Abstract：Objective　To investigate the influence of body mass index (BMI) on the prognosis of patients with type 2 diabetes mellitus (T2DM) after coronary artery bypass grafting (CABG). Methods　A retrospective analysis was performed for the clinical data of 771 patients with T2DM who underwent CABG in Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, from January 1, 2003 to December 31, 2009. According to Chinese BMI standard, the patients were divided into normal weight group, overweight group, and obese group. The primary endpoints were perioperative outcomes, including atrial fibrillation, neurological complications, renal failure, infection, intensive care unit (ICU) stay time, duration of mechanical ventilation, and bleeding, and long-term (5 year) major adverse cardiovascular and cerebrovascular events (MACCEs), including all-cause death, myocardial infarction, heart failure, cerebral infarction, and need for revascularization. Univariate and multivariate Logistic regression analyses, multivariate linear regression analysis, and Cox regression analysis were performed. Results　The Logistic regression analysis and the multivariate linear regression analysis showed that there were no significant differences in atrial fibrillation, neurological complications, renal failure, infection, ICU stay time, duration of mechanical ventilation, and bleeding between the normal weight group and the overweight group or obese group (P>0.05). The Cox regression analysis of 5 year follow-up data showed that there were no significant differences in MACCEs between the normal weight group and the overweight group and obese group (P>0.05). Conclusion　BMI has no marked influence on the prognosis of T2DM patients undergoing CABG
%K 人体质量指数
%K 冠状动脉旁路移植术
%K 非体外循环
%K 糖尿病
%K 2型
%K 超重
%K 肥胖症
%K 预后
%K 回顾性研究
%K 回归分析<br>Body mass index
%K Coronary artery bypass
%K off-pump
%K Diabetes mellitus
%K type 2
%K Overweight
%K Obesity
%K Prognosis
%K Retrospective studies
%K Regression analysis
%U http://jpmed.qdu.edu.cn/CN/10.13362/j.jpmed.201906003