%0 Journal Article
%T Human Plasmodium vivax diversity, population structure and evolutionary origin
%A Ali Ould Mohamed Salem Boukary
%A Antoine Berry
%A Beatriz Acu£¿a Hidalgo
%A Benjamin Mordm¨¹ller
%A Carlo Severini
%A C¨¦line Arnathau
%A Dionicia Gamboa
%A Eric Elguero
%A Eric Legrand
%A Franck Prugnolle
%A Fran£¿ois Nosten
%A Fran£¿ois Renaud
%A Gustavo Fontecha
%A Jean-Fran£¿ois Trape
%A Khadijetou Mint Lekweiry
%A Lilia Gonz¨¢lez-Cer¨®n
%A Lise Musset
%A Mohammad Shafiul Alam
%A Musab Mohamad Albsheer
%A Muzamil Mahdi Abdel Hamid
%A Oscar Noya
%A Patrick Durand
%A Peter Gottfried Kremsner
%A Pingchai Harnyuttanakorn
%A Rashidul Haque
%A Sandrine Houze
%A Sedigheh Zakeri
%A Tamirat Gebru Woldearegai
%A Tepanata Pumpaibool
%A Virginie Rougeron
%J -
%D 2020
%R 10.1371/journal.pntd.0008072
%X More than 200 million malaria clinical cases are reported each year due to Plasmodium vivax, the most widespread Plasmodium species in the world. This species has been neglected and understudied for a long time, due to its lower mortality in comparison with Plasmodium falciparum. A renewed interest has emerged in the past decade with the discovery of antimalarial drug resistance and of severe and even fatal human cases. Nonetheless, today there are still significant gaps in our understanding of the population genetics and evolutionary history of P. vivax, particularly because of a lack of genetic data from Africa. To address these gaps, we genotyped 14 microsatellite loci in 834 samples obtained from 28 locations in 20 countries from around the world. We discuss the worldwide population genetic structure and diversity and the evolutionary origin of P. vivax in the world and its introduction into the Americas. This study demonstrates the importance of conducting genome-wide analyses of P. vivax in order to unravel its complex evolutionary history
%K Plasmodium
%K Population genetics
%K Africa
%K Asia
%K Species diversity
%K Microsatellite loci
%K Evolutionary genetics
%K Parasite evolution
%U https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008072