%0 Journal Article
%T Comparative Analysis of the Macroscale Structural Connectivity in the Macaque and Human Brain
%A Alard Roebroeck
%A Alexandros Goulas
%A Gleb Bezgin
%A Harry B. M. Uylings
%A Matteo Bastiani
%A Peter Stiers
%J -
%D 2014
%R 10.1371/journal.pcbi.1003529
%X The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research
%K Macaque
%K Neural networks
%K Connectomics
%K Centrality
%K Network analysis
%K Primates
%K Prefrontal cortex
%K Tractography
%U https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003529