%0 Journal Article
%T What Is the Most Realistic Single-Compartment Model of Spike Initiation?
%A Romain Brette
%J -
%D 2015
%R 10.1371/journal.pcbi.1004114
%X A large variety of neuron models are used in theoretical and computational neuroscience, and among these, single-compartment models are a popular kind. These models do not explicitly include the dendrites or the axon, and range from the Hodgkin-Huxley (HH) model to various flavors of integrate-and-fire (IF) models. The main classes of models differ in the way spikes are initiated. Which one is the most realistic? Starting with some general epistemological considerations, I show that the notion of realism comes in two dimensions: empirical content (the sort of predictions that a model can produce) and empirical accuracy (whether these predictions are correct). I then examine the realism of the main classes of single-compartment models along these two dimensions, in light of recent experimental evidence
%K Action potentials
%K Axons
%K Neurons
%K Membrane potential
%K One-compartment models
%K Neuronal dendrites
%K Biophysics
%K Ionic current
%U https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004114