%0 Journal Article %T Addressing the context and consequences of substance use, misuse, and dependence: A global imperative %A Alexander C. Tsai %A Margarita Alegr¨ªa %A Steffanie A. Strathdee %J - %D 2019 %R 10.1371/journal.pmed.1003000 %X In an Editorial, Guest Editors Alexander Tsai, Margarita Alegria and Steffanie Strathdee discuss the accompanying Special Issue on Substance Use, Misuse and Dependence %K Opioids %K Death rates %K Alcohol consumption %K Public and occupational health %K Behavioral and social aspects of health %K Canada %K Drug therapy %K Global health %U https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003000