%0 Journal Article
%T Extracts of Potentilla discolor bunge protect islet ¦Â-cells against streptozotocin induced injury
%A Jiangrong Huang
%A Lian Liu
%A Wei Huang
%A Xing Xu
%A Yudong Zheng
%J -
%D 2017
%X Aim: To investigate whether Potentilla discolor Bunge (PDB) extracts could protect islet ¦Â cells and promote cell proliferation and insulin secretion.
Methods: ¦Â-cell injury model was induced by Streptozotocin. Cell viability, insulin secretion and gene expression were measured to investigate the protective effects of PDB extract on RIN-m5f ¦Â cells damaged by streptozotocin.
Results: PDB extracts inhibited cell damage, improved cell viability, promoted insulin secretion, and increased protein level of p-Fox O1 in RIN-m5f ¦Â cells in a dose-dependent manner.
Conclusions: PDB extracts exhibit protective role in streptozotocin induced ¦Â cell injury model. The mechanism may be related to increased phosphorylation of Fox O1, which increases the number and improves the function of ¦Â cells
%K EPD
%K RIN-m5f
%K Protective effect
%K Fox O1
%U https://www.alliedacademies.org/articles/extracts-of-potentilla-discolor-bunge-protect-islet-betacells-against-streptozotocin-induced-injury-7806.html