%0 Journal Article
%T The impact of ¦¤mtDNA4977 mutation on ulcerative colitis
%A Farhd Mashayekhi
%A Kazem Parivar
%A Keyvan Aminian
%A Rasoul Zahmatkesh Roodsari
%A Zivar Salehi
%J -
%D 2017
%X Ulcerative colitis (UC) is an inflammatory bowel disorder characterized by continuous colonic mucosal inflammation that extends proximally from the rectum. The pathogenic mechanisms underlying UC remain unknown. Free-radical-elicited oxidative damage to macromolecules has been established as a contributory factor in UC. It is well known that the mitochondrial genome is more susceptible to increased oxidative damage than nuclear DNA. One of the best-described mtDNA mutations is the ¦¤mtDNA4977 (mtDNA 4977 bp) or common deletion. The aim of this study was to investigate the relationship between ¦¤mtDNA4977 and UC. We studied the ¦¤mtDNA4977 150 patients with UC (64 men, 86 women; mean age, 36.7 ¡À 11.6 years) and 250 disease-free controls (137 men, 113 women; mean age, 35 ¡À 12.1 years) in northern Iran. After DNA extraction from colon biopsies, gap polymerase chain reaction (Gap-PCR) was performed. The frequency of ¦¤mtDNA4977 was significantly different between the UC patients and the control group (78.7% vs. 16.8%, P<0.001). We found that ¦¤mtDNA4977 was more likely to be present in the patients of younger age (¡Ü 50 years, P=0.021). The mtDNA deletion was also significantly associated with the increased risk of an extensive form of colitis. Our study indicates that the ¦¤mtDNA4977 may play a role in the pathogenesis of UC. However, the findings need to be verified in large population-based prospective studies for more rigorous analyses of subgroups
%K Ulcerative colitis
%K £¿£¿£¿£¿mtDNA4977
%K Mutation
%K mtDNA deletion
%U https://www.alliedacademies.org/articles/the-impact-of-deltamtdna4977-mutation-on-ulcerative-colitis.html