%0 Journal Article
%T Laparoscopic versus open appendectomy on serum levels of cytokines in children with perforated appendices, peritonitis and sepsis
%A Bian Hongqiang
%A Duan Xufei
%A Mei Hong
%A Yan Xueqiang
%A Yang Jun
%A Ye Guogang
%A Zhou Shiqiong
%J -
%D 2017
%X Purpose: To examine the effect of Laparoscopic (LA) and Open Appendectomy (OA) on serum levels of inflammatory factors Interleukin-6 (IL-6) and Tumor Necrosis Factor-¦Á (TNF-¦Á) and anti-inflammatory factor, Interleukin-10 (IL-10), in children with perforated appendices, peritonitis and sepsis.
Methods: 36 children received LA and 31 children received OA were included. Serum IL-6, TNF-¦Á and IL-10 were determined at different time points before and after surgery with double-antibody sandwich ELISA.
Results: Preoperative serum IL-6, TNF-¦Á and IL-10 were not significantly different between LA group and OA group (P>0.05). However, serum IL-6 and TNF-¦Á in LA group were significantly lower than those in OA group on postoperative days 1, 3 and 7 (all P<0.05). Serum IL-10 in LA group was initially higher than that in OA group on postoperative days 1 and 3 (P<0.05), but became significantly lower than that in OA group on postoperative day 7 (P<0.05).
Conclusion: Decreased inflammatory response and enhanced anti-inflammatory response were evident postoperatively in children received LA reflected by reduced serum IL-6 and TNF-¦Á, and increased serum IL-10, suggesting LA is a better choice over OA
%K Perforated appendix
%K Laparoscopic appendectomy
%K Open appendectomy
%K Inflammatory factor
%K Children
%U https://www.alliedacademies.org/articles/laparoscopic-versus-open-appendectomy-on-serum-levels-of-cytokines-in-children-with-perforated-appendices-peritonitis-and-sepsis-8095.html