%0 Journal Article %T Asiaticoside improves spatial learning and memory abilities of Alzheimer's disease rat model by promoting the expression of PPA¦Ã and inhibiting inflammatory factors %A Daqiang Song %A Fang Wang %A Hong Zhang %A Siwei Chen %A Xian Jiang %A Zhuo Zhang %J - %D 2018 %R 10.4066/biomedicalresearch.29-17-2073 %X Aims: The present study is to investigate the effect of Asiaticoside (AS) on the expression of hippocampal Peroxisome Proliferator Activated Receptor Gamma (PPAR¦Ã) and inflammatory factors such as Interleukin (IL)-6 and Tumor Necrosis Factor (TNF)-¦Á in rats after intracerebral injection of A¦Â1-42. Methods: A total of 40 specific pathogen-free Sprague-Dawley rats were evenly divided into shamoperation (control) group, model group, model+AS (15 mg/kg) group and model+AS (45 mg/kg) group. Condensed ¦Â-amyloid protein (A¦Â)-1-42 was slowly injected into the CA1 region in hippocampus of rats to simulate Alzheimer¡¯s disease. Morris water maze test was used to examine the ability of spatial learning and memory of rats. Immunohistochemistry was performed to detect the deposition of A¦Â1-42 in hippocampal tissues. Enzyme-linked immunosorbent assay was carried out to determine the contents of IL-6 and TNF-¦Á in hippocampal tissues. Western blotting was employed to measure the protein expression of PPAR¦Ã. Results: Treatment with AS enhanced the spatial learning and memory, reduced the expression of A¦Â1-42 in hippocampal region, decreased the contents of IL-6 and TNF-¦Á in hippocampal tissues, and elevated the protein expression of PPAR¦Ã in hippocampal tissues of AD model rats. Conclusions: The present study demonstrates that AS improves spatial learning and memory abilities of AD model rats by promoting the expression of PPAR¦Ã and inhibiting the contents of inflammatory factors %K Asiaticoside %K Peroxisome proliferator activated receptor-£¿£¿£¿£¿£¿£¿£¿3 %K Inflammation %K Alzheimer£¿£¿£¿¡é£¿£¿£¿£¿£¿£¿£¿£¿s disease %U https://www.alliedacademies.org/articles/asiaticoside-improves-spatial-learning-and-memory-abilities-of-alzheimers-disease-rat-model-by-promoting-the-expression-of-ppagamm-9955.html