%0 Journal Article
%T Alterations in Total Sialic Acid (TSA), Total Proteins (TP) and TSA/TP ratio in cancer patients
%A Ajit Sontakke
%A P
%A P.S. Shukla
%A Pratik Durgawale
%A Pushpa Durgawale
%A urang Chougule
%J -
%D 2011
%X Total serum sialic acid (TSA), total proteins (TP) and TSA/TP ratio (as tumor markers) have been estimated in 108 cancer patients, 30 pathological controls and 50 normal healthy controls. Data analysis indicated a significant increase (p< 0.001) in the TSA and TSA/TP ratio in cancer patients (98.41 ¡À 13.5 mg/dl and 15.31 ¡À 2.57 mg/gm) as compared to patho-logical controls (77.57 ¡À 21.09 mg/dl and 11.94 ¡À 3.43 mg/gm) and normal control (64.77 ¡À 7.98 mg/dl and 8.9 ¡À 1.15mg/gm) respectively. A significant decrease (p<0.001) in serum lev-els of total proteins were found in all cases of cancer compared to the normal (6.46 ¡À 0.48 mg/dl and 7.29 ¡À 0.55 gm/dl) and pathological controls (6.53 ¡À 0.36 gm/dl).Further analysis of the data in patient subgroups of malignancy based on tissue involved indicated that the lack of specificity of the markers but the sensitivity of TSA and TSA/TP increased as the malignancy become more severe. The results show that TSA/TP was the most useful marker for detecting malignancie
%K Sialic acid
%K Serum protein
%K Cancer
%U https://www.alliedacademies.org/articles/alterations-in-total-sialic-acid-tsa-total-proteins-tp-and-tsatp-ratio-in-cancer-patients.html