%0 Journal Article
%T Dopamine (DA) toxicity in pathogenesis and therapy of Parkinson's disease (PD).
%A Eng King Tan
%A Zhi Dong Zhou
%J -
%D 2017
%X Parkinson?s disease (PD) is the second most common neurodegenerative disorder that affects 1% of the general population over the age of 60 [1]. PD is characterized by progressive dopamine (DA) neuron degeneration in the pars compacta of the substantia nigra (SN) plus Lewy body formation in affected brain areas [2]. The progressive DA neuron degeneration leads to decreased DA content in SN, contributing to onset of PD symptoms. So far PD is still an incurable human disorder and L-DOPA replenishing therapy is the only treatment, which can transiently alleviate PD symptoms, with no therapeutic effects against DA neurons demise in PD patient brain
%K Parkinson？？？？？？？？？？？？？？？￠？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？？s disease
%K toxicity
%K mutations
%U https://www.alliedacademies.org/articles/dopamine-da-toxicity-in-pathogenesis-and-therapy-of-parkinsons-disease-pd-8683.html