%0 Journal Article
%T Oral serum bovine immunoglobulin improves IBS-D symptoms analyzed from patient medical charts.
%A Audrey Shaw
%A Brooke Jackson
%A Bruce P. Burnett
%A David Wei
%A Larry Good
%A Raymond Panas
%A Ren£¿ E. Vasquez
%A The SBI Retrospective Study Group
%A Tim Bradshaw
%J -
%D 2017
%R 10.35841/biology-medicine.1.1.16-23
%X Purpose: To examine clinical practice effectiveness of a medical food containing serum-derived bovine immunoglobulin (SBI) for the management of symptoms in irritable bowel syndrome with diarrhea (IBS-D) patients.

Methods: From 165 IBS-D patient medical charts [mean age=59.6 years (range: 19-98), female (n=109), Caucasian (n=144)], recorded daily stools/consistency, abdominal pain, and patient/ physician reported quality of life (QoL) scores were retrospectively collected on those prescribed SBI for a minimum of 8 weeks. A generalized estimating equations model was used to analyze and compare changes for scores of symptoms and QoL.



Results: Where data existed in charts, 46% of patients on SBI had a combined mean score reduction in daily stools, improvement in stool consistency (Bristol Stool Scale from >5 to <5) and decrease in abdominal pain (?30%). Significant improvements (p<0.001) in individual symptom and QoL scores with a high response were also reported for daily stools (76%), consistency (78%), abdominal pain (69%), as well as patient (79%) and physician QoL (73%). Eleven patients experienced 13 adverse events (AEs) while receiving SBI with nausea (n=6) most prevalent. No serious AEs were reported, but 4 patients discontinued SBI.

Conclusion: In this retrospective chart analysis of IBS-D patients who took a medical food containing SBI for 8 weeks, there were statistical improvements in daily stool number, stool consistency, abdominal pain and QoL scores supporting its use IBS-D
%K Irritable bowel syndrome
%K Diarrhea
%K Abdominal pain
%K Treatment response
%K Functional bowel
%K Serum-derived immunoglobulin.
%U https://www.alliedacademies.org/articles/oral-serum-bovine-immunoglobulin-improves-ibsd-symptoms-analyzed-from-patient-medical-charts-8066.html