%0 Journal Article
%T Effect of alpha lipoic acid on cognitive function and oxidative stress in STZ diabetic rats
%A Hongyan Li
%A Hongyan Zhang
%A Jie Li
%A Mengjia Kong
%A Qingjiu Zhang
%A Songyun Zhang
%J -
%D 2017
%X Objective: To observe the role of alpha lipoic acid (¦Á-LA) and oxidative stress in STZ diabetic rats.
Methods: Male SD rats were randomly divided into 3 groups: Normal control group (NC, n=10); Diabetes control group (DC, n=10) and Diabetes lipoic acid group (DL, n=10), feeding for 18w. From 12 to 18w, ¦Á-LA (60 mg/kg) was given to DL group. Morris water maze test was evaluated in the 12th and 18th week. MDA, p22phox (NADPH oxidase subunit), SOD and GSH-Px levels of hippocampal tissue were determined in the 18th week.
Results: the escape latency period: 12w, DC>DL>NC group (P<0.05); 18 w, DC>DL group>NC group (P<0.05). MDA p22phox, NADPH oxidase subunit: DC group>DL>NC group (P<0.05). SOD and gsh-px: D
%K Diabetes mellitus
%K Rats
%K Cognitive function
%K Alpha lipoic acid
%K p22phox0
%U https://www.alliedacademies.org/articles/effect-of-alpha-lipoic-acid-on-cognitive-function-and-oxidative-stress-in-stz-diabetic-rats.html