%0 Journal Article
%T Anticancer effects of Gardenia jasminoides in HepG2 human hepatoma cells
%A Jun Qian
%A Rui Wang
%A Ruo-kun Yi
%A Shao-cheng Chen
%A Xin Zhao
%A Yan-hong Shi
%J -
%D 2017
%X Background: Gardenia jasminoides is a natural plant, it has many biological activities. Its ability of cancer cell apoptosis needs to be researched.
Methods: In this study, the important biological activity materials were determined by high efficiency liquid chromatography. The in vitro anticancer effects were measured by MTT and RT-PCR assays in HepG2 human hepatoma cells.
Results: Gardenia jasminoides contained 1.03% genipin gentiobioside, 5.90% gardenoside, 1.26% crocin 1 and 0.17% crocin 2. Gardenia jasminoides had significantly strong HepG2 cells inhibitory effects, and highest effect 80.2% is showed in 400 ¦Ìg/mL concentration of Gardenia jasminoides which is remarkable. the Gardenia jasminoides also have the ability to increase the mRNA expression of caspase-3, caspase-8, caspase-9, Bax, TRAIL, Fas, Fas/FasL, p53, p21, I¦ÊB-¦Á and decrease the Bcl-2, BclxL, XIAP, cIAP-1, cIAP-2, survivin, NF-¦ÊB expression in HepG2 cells. The higher concentration of Gardenia jasminoides also showed the higher increasing or decreasing mRNA expression effects in HepG2 cells.
Conclusion: Gardenia jasminoides had a strong anticancer effect through its apoptosis inducing abilities in hepatic cancer; it could be used for the treatment as a medicine or health product in daily human life for good liver health
%K Gardenia jasminoides
%K Apoptosis
%K mRNA
%K HepG2 human hepatoma cells
%K Anticancer
%U https://www.alliedacademies.org/articles/anticancer-effects-of-gardenia-jasminoides-in-hepg2-human-hepatoma-cells.html