%0 Journal Article
%T 5¦Á-reductase inhibitors and anti-prostate cancer activities of some synthesized 4`-(aryl)-4-pregneno[3,2-e]pyridinone derivatives
%A Abd El-Galil E Amr
%A Hany M Safwat
%A Mohamed H Elgamal
%A Mohamed M Abdalla
%A Mohamed MM Hussein
%J -
%D 2017
%X A series of 2`-mercapto-3`-cyano-4`-(aryl)-4-pregneno-[3,2-e]pyridine-20-ones (3a-h) and 1`- thiocarbamoyl -2`-amino-4`-(aryl)-4-pregneno-[3,2-e]pyridine-20-one derivatives (4a-h) were synthesized using progesterone 1 "17-acetyl-1,7,8,10,11,12,13,15,16,17-decahydro-10,13-dimethyl-2Hcyclopenta[ a]phenanthren-3(6H,9H,14H)-one" as starting material. The synthesized compounds were evaluated for 5¦Á-reductase inhibitors and anti-prostate cancer activities compared to Anastrozole£¿ as positive control. Some of the tested compounds exhibited better activities than Anastrozole£¿. Compounds 3a-h and 4a-h showed potent 5¦Á-reductase inhibitors and anti-prostate cancer activities than Anastrozole£¿
%K Progesterone
%K pregneno[3
%K 2-e]pyridinones
%K 5£¿£¿£¿£¿£¿£¿£¿¡À-reductase inhibitor
%K anti-prostate cancer
%U https://www.alliedacademies.org/articles/5alphareductase-inhibitors-and-antiprostate-cancer-activities-of-some-synthesized-4aryl4pregneno32epyridinone-derivatives.html