%0 Journal Article
%T Anticancer evaluation of novel 1,3,4-trisubstituted pyrazole candidates bearing different nitrogenous heterocyclic Moieties
%A Eman S. Nossier
%A Hend M. EL-Sahrawy
%A Hoda H. Fahmy
%A Magda M. F. Ismail
%A Nagy M. Khalifa
%J -
%D 2016
%X With the goal of developing novel and potent anticancer therapies, a new set of 1,3,4-trisubstituted pyrazole derivatives linked to different heteroaryl systems at C-4 position were prepared and estimated for their anticancer effects at NCI, USA employing a two stage procedure using 60 various human tumor cell lines. Anticancer evaluation disclosed that, compound 4c displayed super fat potency towards most human tumor cell lines with GI50 (0.52-5.15 ¦ÌM), particularly against colon SW-620 cell line with GI50 (0.52 ¦ÌM). At the same time, 4c was also selective against A498 and RXF 393 cell lines of renal cancer with GI50 0.58 and 0.86 ¦ÌM respectively
%K Anticancer evaluation
%K 1
%K 3
%K 4-trisubstituted pyrazoles
%K Synthesis
%U https://www.alliedacademies.org/articles/anticancer-evaluation-of-novel-134trisubstituted-pyrazole-candidates-bearing-different-nitrogenous-heterocyclic-moieties.html