%0 Journal Article
%T Alkaloids from root tubers of Stephania kwangsiensis H.S.Lo and their effects on proliferation and apoptosis of lung NCI-H446 cells.
%A Dong Hu
%A Ling Rong
%A Runpeng Zhao
%A Wan Wang
%A Wu Jing
%A Xuewei Xu
%J -
%D 2016
%X To study the chemical constituents of Stephania kwangsiensis Lo. and to explore the effects of corydine on proliferation and apoptosis of lung adenocarcinoma NCI-H446 cells. Chemical structures were elucidated by MS, 1H-NMR and 13C-NMR. Effects of different concentrations of corydine on proliferation of lung adenocarcinoma NCI-H446 cells were determined by MTT assay. Effects of corydine on apoptosis rate of NCI-H446 cells were determined by flow cytometry. Three types of alkaloids were isolated from root tubers of Menispermaceae Stephania plant Stephania kwangsiensis Lo. Three different concentrations of corydine (20, 10, 5 Lg/ml) could all significantly increase the apoptosis rate of NCI-H446 cells after 48 h of treatment compared to the control group. Corydine can inhibit the proliferation of lung cancer NCI-H446 cells and induce their apoptosis
%K Stephania kwangsiensis Lo.
%K corydine
%K small cell lung cancer
%K apoptosis
%U https://www.alliedacademies.org/articles/alkaloids-from-root-tubers-of-stephania-kwangsiensis-hslo-and-their-effects-on-proliferation-and-apoptosis-of-lung-ncih446-cells.html