%0 Journal Article
%T A Prospective-Observational Study to Assess the Prevalence of Adverse Drug Reactions in MDR-TB Patients at Tertiary Care Hospital in India
%A Ashishkumar C Zala
%A Dharna Patel
%A Dhruv Patel
%A N D kantharia
%A Ruchita Manvar
%J -
%D 2015
%X Background: Adverse Drug Reactions (ADRs) constitute an enormous burden for the society. The aim of the present study was to detect, document, assess and report the suspected ADRs.
Methods: A prospective-observational study was conducted in the Department of Pulmonary Medicine of a tertiary care hospital for 12 months from April 2014 to March 2015. Patients on RNTCP (Revised National Tuberculosis Control Programme, India) MDR-TB (Multidrug resistant tuberculosis) regimen were enrolled. Detected and suspected ADRs were analysed for causality, severity and preventability using appropriate validated scales and were reported. 
Results: A total of 121 ADRs were detected, documented, assessed and reported during the study period. Assessment of severity of the suspected ADRs revealed that 23.14% of suspected ADRs were severe and 28.29% of ADRs were moderate in severity. Causality assessment was done which revealed 61.1% of ADRs were certainly drug-related. The majority of patients who had suffered from ADRs were above 20 years. Ototoxicity was most common (37%) and the drug mostly associated with ADRs was kanamycin (27%). Preventability of ADRs was assessed; and the results revealed that 15.7 % of ADRs were definitely preventable. 
Conclusions: Measures to improve detection and reporting of adverse drug reactions by all health care professionals is recommended to be undertaken, to ensure, and improve patient's safety and adherence to MDR-TB regimen
%K Ashishkumar C Zala
%K Ruchita Manvar
%K Dhruv Patel
%K Dharna Patel
%K Nitesh Gamit and N D kantharia
%K Adverse Drug Reactions (ADR)
%K Prevalence
%K MDR-TB
%K India
%U https://www.imedpub.com/abstract/a-prospectiveobservational-study-to-assess-the-prevalence-of-adverse-drug-reactions-in-mdrtb-patients-at-tertiary-care-hospital-in-india-10157.html