%0 Journal Article
%T Relationship of Genetic Polymorphism (Intronic SNP RS2606345 of CYP1A1) and Drug Response in North Indian Epileptic Patients & Controls
%A Das S
%A Mazumder A
%A Upadhyay C
%J -
%D 2017
%R 10.21767/2393-8854.100026
%X It	is	observed	that	many	of	the	epilepsy	patients	fail	to	achieve	good	response	to	treatment,	leading	to	increased	risk	of	death	and	psychosocial	consequences.	Many	hypotheses	have	been	given	regarding	this	variable	response	like	variation	in	Drug	metabolizing	enzyme	(DME).	The	role	of	one	such	DME	i.e.,	CYP1A1,	has	been	evaluated	in	this	study	which	is	known	to	metabolize	estrogen	into	its	various	metabolites.	Estrogen	is	observed	to	play	a	role	in	causing	seizures	interfering	with	normal	brain	function.	One	of	its	important	SNP	rs2606345	is	observed	to	play	a	key	role	in	seizure	occurrence.	The	intronic	SNP	IVS1+606C>A	shows	no	response	to	AEDs.
%K Genetic	polymorphism
%K Drug	response
%K Epilepsy
%K list of open access journals
%K open access
%K open access journals
%K open access publication
%K open access publisher
%K open access publishing
%K open access journal articles
%K imedpub
%K imedpub publishing
%K insight medical publishing
%K imedpub online
%U https://www.imedpub.com/articles/relationship-of-genetic-polymorphism-intronic-snp-rs2606345-of-cyp1a1-and-drug-response-in-north-indian-epileptic-patients--contro.php?aid=20372