%0 Journal Article
%T Antidiabetic Potentials of Leaves Extract of
Barringtonia Racemosa (L) in Alloxan-Induced
Albino Rats
%A Ayobami Jahdahunsi Kukoyi
%A Hauwa A Umaru
%A Isaac John Umaru
%A Kanati Madaki
%A Kerenhappuch I Umaru
%A Mida H Miyel
%A Richard-Harris Boyi
%J -
%D 2018
%R 10.21767/2393-8862.100015
%X Objective: Diabetes mellitus is a heterogeneous group of metabolic disorders   characterized by persistent hyperglycaemia and becoming a serious threat to   mankind health in all parts of the world. This study was designed to study the   methanol leaf extract potential of Barringtonia Racemosa on Alloxan-induced   diabetic.
Materials and Methods: The experimental rats were induced and made diabetic   by single intra-peritoneal administration of Alloxan monohydrate at a dose rate   of 160 mg/kg dissolved in 0.1 M freshly prepared citrate buffer at a base line pH   4.5. Extract of Barringtonia Racemosa (100, 200, 300, 400 and 500 mg/kg). Group   1 (normal rats) were administered distilled water, Group 2 (Diabetic untreated   rats) were administrated distilled water, while Group 3 received the standard drug (Insulin) at 0.1 mg/kg and the rest of the groups 5-8 were administered the   methanol extracts. Blood glucose was determined by glucose oxidase method of   Trinder.
Results: The blood glucose data obtained using Alloxan hyperglycaemic rats,   dose of the methanol extract indicated a significant difference in the level of   blood glucose with increase in the extract concentration at different days of   administration (p<0.05) with 053.4 ¡À 5.5 and 045.5 ¡À 5.8 higher than the control   066.6 ¡À 5.2 at 400 mg/kg and 500 mg/kg post treatment.
Conclusion: The blood glucose data obtained using Alloxan hyperglycaemic rats   clearly shows that the methanol extract of Barringtonia Racemosa can produce   significant and consistent hypoglycaemic effects.
%K Antidiabetic
%K Barringtonia racemosa
%K Alloxan
%K Albino rats
%K list of open access journals
%K open access
%K open access journals
%K open access publication
%K open access publisher
%K open access publishing
%K open access journal articles
%K imedpub
%K imedpub publishing
%K insight medical publishing
%K imedpub online
%U https://www.imedpub.com/articles/antidiabetic-potentials-of-leaves-extract-ofbarringtonia-racemosa-l-in-alloxaninducedalbino-rats.php?aid=23407