%0 Journal Article
%T Stability Indicating RP-HPLC Method for Determination of Drotaverine HCL and  Mefenamic Acid in Pure and Pharmaceutical Formulation
%A A.R. Umarkar
%A M.M. Bari
%A Pallavi A. Patil
%A S.D. Barhate
%J -
%D 2015
%X Objective: A Stability indicating Reverse-Phase liquid chromatographic method for the simultaneous estimation of Drotaverine HCl and Mefenamic acid was developed.
Method: The chromatographic assay involves the use of Hi Q C-18 W (5¦Ìm column with a simple mobile phase containing 80:20% v/v of methanol & HPLC Grade water (0.1% triethylamine at pH 3) with flow rate of 1.0mL/min with UV detection at wavelength of 250 nm.
Result: The method showed good linearity in the concentration range of 2-10 ¦Ìg/mL for Drotaverine Hcl and 6-30 ¦Ìg/mL for Mefenamic Acid.
Conclusion: The developed method was successfully validated as per the ICH guidelines. The stability indicating capacity was also tested and successfully applied to marketed formulation
%K Pallavi A. Patil
%K A.R. Umarkar
%K M.M. Bari and S.D. Barhate
%K Drotaverine hydrochloride
%K Mefenamic acid
%K Stability
indicating
%K RP-HPLC
%K Force degradation study
%U https://www.imedpub.com/abstract/stability-indicating-rphplc-method-for-determination-of-drotaverine-hcl-and--mefenamic-acid-in-pure-and-pharmaceutical-formulation-11029.html