%0 Journal Article
%T Validation of the RP-HPLC method for analysis of captopril in
pharmaceutical tablets
%A B. Jebaslinhepzybai1
%A C. Velmurugan2
%J -
%D 2016
%X A simple and sensitive reversed-phase liquid chromatographic method has been developed and validated for the analysis of Captopril in bulk and its tablet dosage form. The separation was carried out on LC1(C18) coloum (250 ¡Á 4.6mm; 5¦Ìm) column at ambient temperature using methanol and water (55:45) as eluent. The flow rate was 1.0 ml/min and Captopril was quantified by absorbance at 220 nm. The retention time of Captopril was 7.20 min. The percentage recovery was within the range between 100.05 % and 100.79% for Captopril. The linear ranges were found in the range of 80¦Ìg/ml ¨C 120¦Ìg/ml (r2 = 0.999) of Captopril. The percentage relative standard deviation for accuracy and precision was found to be less than 2%. Hence, the proposed method could be successfully employed for routine analysis of Captopril in pharmaceutical formulations according to ICH guidelines
%K B. Jebaslinhepzybai1
%K C. Velmurugan2 and A. Chenthilnathan1*
%U https://www.imedpub.com/abstract/validation-of-the-rphplc-method-for-analysis-of-captopril-inrnpharmaceutical-tablets-11601.html