%0 Journal Article
%T Relative Influence of adrenergic £¿2-agonist and antagonist on the inflammation and their interaction with aspirin
%A J. V. Manwar
%A S. S. Padgilwar
%J -
%D 2013
%X Aim of the present study was to evaluate the effects of adrenergic ¦Â-agonist and antagonist on acute and subacute
  inflammation and to study their possible interaction with aspirin, a commonly used NSAID. Propranolol in the dose
  of 4.5 mg/kg, 9 mg/kg, atenolol in the dose of 1mg/kg and 4.5 mg/kg, terbutaline in the dose of0.45mg/kg and
  0.9mg/kg and aspirin in the dose of 54,200 mg/kg were administered orally in different groups of albino rats, to
  study their effect on inflammation induced by carrageenan or a foreign body. Aspirin (54 mg/kg) was administered
  with terbutaline (0.45 mg/kg) propranolol and atenolol (4.5mg/kg and 1mg/kg) to separate groups in order to study
  their interaction. Terbutaline, propranolol and atenolol produced significant anti-inflammatory activity in acute as
  well as sub acute inflammation model except atenolol in sub acute model. Sub anti-inflammatory (low dose) dose of
  terbutaline potentiated the anti-inflammatory activity of aspirin where as propranolol and atenolol failed. In
  conclusion, adrenergic ¦Â agonist and antagonist showed significant anti-inflammatory activity and coadministration
  with aspirin potentiated anti-inflammatory response of aspirin.
%K Aspirin
%K anti-inflammatory agent
%K terbutaline
%K propranolol and atenolol
%K list of open access journals
%K open access
%K open access journals
%K open access publication
%K open access publisher
%K open access publishing
%K open access journal articles
%K imedpub
%K imedpub publishing
%K insight medical publishing
%K imedpub online
%U https://www.imedpub.com/articles/relative-influence-of-adrenergic-agonist-and-antagonist-on-the-inflammation-and-their-interaction-with-aspirin.php?aid=12015