%0 Journal Article
%T Effect of Supplementation of Natural Honey
on Serum Albumin and Total Protein of
Alloxan Induced Diabetic Wister Rats
%A Chike CPR
%A Chuemere A N
%A Nyeche S
%J -
%D 2017
%X Background: Diabetes mellitus is a metabolic disorder that is associated with   abnormalities in most biochemical markers including depletion of proteins as a   result of its excessive catabolism and/or diminished synthesis. The present study   is aimed at determining the changes that may occur in the levels of albumin and   total proteins following 8-week supplementation of honey in diabetic rats.
Methods: 48 male Wister rats weighing 200-250 g separated into 6 groups of 8   rats each were used for the experiment; Groups 1 and 3 are non-diabetic and   diabetic controls respectively. Group 2 is non-diabetic test group which received   10 ml/kg/day of 50% honey whereas groups 4, 5 and 6 are diabetic test groups   which received 10 ml/kg/day of 10%, 30% and 50% honey respectively. Diabetes   was induced in groups 3 to 6 by intraperitoneally injecting 2% alloxan solution as   200 mg/kg and confirmed with a blood sugar ¡Ý 12.0 mmol/l. The animals were   sacrificed at the end of 8 weeks and blood samples collected to measure the levels   of albumin and total protein.
Results: The results showed that 8-week honey supplementation significantly   increased the serum concentrations of albumin in both diabetic and non-diabetic   rats. There was however, no significant change in the levels of total protein in both   diabetic and non-diabetic rats.
Conclusion: Our findings suggest that honey may have a possible anti-catabolic   effect on albumin and may also protect the hepatocytes from the oxidative stress   in diabetes with resultant improved synthesis of albumin
%K Obia O
%K Chuemere A N
%K Chike CPR and Nyeche S
%K Honey
%K Albumin
%K Total protein
%K Diabetic rats
%U https://www.imedpub.com/abstract/effect-of-supplementation-of-natural-honeyrnon-serum-albumin-and-total-protein-ofrnalloxan-induced-diabetic-wister-rats-21255.html