%0 Journal Article
%T Synthesis and antihypertensive activity of 4'-{2-[4-[2-(Substitutedphenyl)- 4-oxo-thiazolidin-3-yl]-phenyl} benzoimidazol-1-yl-methyl}- biphenyl-2-carboxylic acids
%A A. D. Sharma
%A D. V. Kohli
%A Smita Sharmab
%J -
%D 2010
%X Structures of all the synthesized compounds have been corroborated on the basis of elemental IR, 1H NMR, 13C NMR and Mass spectro-analytical data. Many Schiff bases were prepared by condensation reaction of compounds containing biphenyl carboxylic acid with aromatic aryl aldehydes derivatives with Thiazoldine-4-one. The synthesized compounds 4'-{2-[4-[2- (Substituted-phenyl)-4-oxo-thiazolidin-3-yl]-phenyl} benzoimidazol-1-ylmethyl}-biphenyl-2- carboxylic acid react with mercaptoacetic acid and 4'-bromomethylbiphenyl-2-carboxylic acid and all synthesis compounds screened for Angiotension (A II) Receptor Antagonist antihypertensive activity with biphenyl carboxylic acid Schiff bases Thiazoldine-4-one shows good activity compared with losartan and Telmisartan
%K M. C. Sharma
%K D. V. Kohli
%K Smita Sharmab and A. D. Sharma
%K Biphenyl carboxylic acid
%K Thiazoldine-4-one
%K Angitotensin II
%K antihypertensive drug
%K Losartan
%K Telmisartan
%U https://www.imedpub.com/abstract/synthesis-and-antihypertensive-activity-of-4242substitutedphenyl-4oxothiazolidin3ylphenyl-benzoimidazol1ylmethyl-biphenyl2carboxylic-acids-16842.html