%0 Journal Article
%T Formulation and Evaluation of Taste Masked Doxycycline HCl Medicated Jelly
%A Asma Nawaz
%A Kashif Kamboh
%A Muhammad Mohsin Javaid
%A Shahnila Aslam
%A Syed Nisar Hussain Shah
%J -
%D 2017
%X Aim: The aim of present study was to formulate and evaluate the taste mask Doxycycline HCl medicated oral jelly by making complex with ¦Â cyclodextrin.
Methods: The slurry was prepared by using glucose 53%, sugar 34%, gelatin 25% and sorbitol 2.52%. All physicochemical characteristics like viscosity, homogeneity and viscosity, pH, synersis, palatability and taste were performed on this medicated jelly.
Results: In vitro dissolution studies were performed on this formulation in artificial saliva which showed maximum 99.3% drug release within 20 min. The release pattern of this medicated jelly followed the first order release kinetics. Stability study at 40 ¡À 5oC was performed for three months which has shown the satisfactory result.
Conclusion: Doxycycline HCl is absorbed from buccal mucosa as well as from GIT. The chewing has shown drug release of greater than 90%. Thus it can be said that oral medicated jelly of Doxycycline HCl was made successfully
%K Syed Nisar Hussain Shah
%K Shahnila Aslam
%K Hina Javed*
%K Asma Nawaz
%K Kashif Kamboh and Muhammad Mohsin Javaid
%K Doxycycline
%K ¦Â-cyclodextrin
%K Medicated oral jelly
%K Artificial saliva
%K Ex-vivo release study
%U https://www.imedpub.com/abstract/formulation-and-evaluation-of-taste-masked-doxycycline-hcl-medicated-jelly-19936.html