%0 Journal Article
%T Crystallization and Nanostructural Features of Metformin Drug an AFM-Investigations
%J -
%D 2015
%X Objective: Studying the impact of three different types of organic solvent namely toluene, methanol and acetone on the main crystallographic phase of metformin drug.
Methods: Calculations of solubilities rates accompanied with XRD analyses, plus accurate monitoring of metformin microstructural features as function of applied solvent of crystallization process.
Results: XRD analyses indicated that applied solvent has no impact on the crystal structure of metformin. The roughness of metformin surface¡¯s were monitored by using high resolution SEM and AFM-microscope. Conclusion: Surface roughness plays an important role on dissolution rates process and consequently solvation rates. Enhancing or decreasing dissolution rates could be benefit in metformin drug industrie
%K Khaled M. Elsabawy
%K Metformin
%K XRD
%K Microstructure
%K AFM
%K Roughness
%K Dissolution rate
%U https://www.imedpub.com/abstract/crystallization-and-nanostructural-features-of-metformin-drug-an-afminvestigations-10146.html