%0 Journal Article
%T Synthesis and in vitro antibacterial studies of some novel 3-(5-amino-6(2, 3-dichlorophenyl)-1, 2, 4-triazin-3-yl)-2-aryl quinazoline-4(3H)-one
%A S.Kavimani
%J -
%D 2010
%X In the present study some new 3-(5-amino-6(2, 3-dichlorophenyl)-1, 2, 4-triazin-3-yl)-2-arylquinazoline- 4(3H)-ones (3a-3f) was synthesized. The newly synthesized compounds were characterized on the basis of elemental analysis, IR and 1H-NMR spectra. All the synthesized compounds were tested for their antibacterial activity against 20 strains of Gram positive and Gram negative bacteria. Among the compounds tested, the compounds 3a & 3f showed good antimicrobial activity in comparison to standard sulphamethoxazole. Compound 3f was found to be most active in the series against H. pylori with MIC 25 ¦Ì g/mL
%K G.Nagarajan and S.Kavimani
%K Quinazolinones
%K in-vitro antibacterial activity
%K MIC value
%U https://www.imedpub.com/abstract/synthesis-and-in-vitro-antibacterial-studies-of-some-novel-35amino62-3dichlorophenyl1-2-4triazin3yl2aryl-quinazoline43hone-16936.html