%0 Journal Article
%T Synthesis and Anti-Proliferative Activity of Biphenyl Derived 5-Substituted-Indolin-2-Ones
%A Atulkumar A Kamble
%A Mahadev N Kumbar
%A Ravindra R Kamble
%A Sheshagiri R Dixit
%A Shrinivas D Joshi
%J -
%D 2017
%R 10.21767/2572-4657.100004
%X A series of novel biphenyl derived   5-substituted-indolin-2-one derivatives were synthesized by the reaction   of 6-chloro-5-(2-chloroethyl)-indolin-2-one 1 with cyclic secondary   amines 2a-h followed by condensation of bromomethylcyanobiphenyl to   afford the compounds 5a-h. The nitrile group of 5a-h was converted into   tetrazole to obtain the compounds 7a-h and tetrazole of 7a-h was further   ring transformed into oxadiazole to get compounds 8a-h. Molecular   docking study of these previously unknown molecules was performed on   PDB: 453D to analyze the interaction and preferred binding mode of   synthesized molecules with DNA. Anti-proliferative activity of these   newly synthesized compounds were evaluated against a panel of 60 human   cancer cell lines at National Cancer Institute (NCI), Bethesda USA.   Among these, seven (07) compounds were evaluated for their anti-cancer   activity. Some of the compounds displayed potent anti-proliferative   activity at 10 ¦ÌM
%K Gangadhar Y Meti
%K Ravindra R Kamble
%K Atulkumar A Kamble
%K Mahadev N Kumbar
%K Shrinivas D Joshi
%K Sheshagiri R Dixit
%K Indolin-2-ones
%K Biphenyl
%K Tetrazole
%K Oxadiazole
%K Anti-proliferative activity
%K Docking
%K DNA
%U https://www.imedpub.com/abstract/synthesis-and-antiproliferative-activity-of-biphenyl-derived-5substitutedindolin2ones-17716.html