%0 Journal Article
%T A Comparison of the Liver Fat Score and CT Liver-to-Spleen Ratio as Predictors of Fatty Liver Disease by HIV Serostatus
%A Chi-Hong Tseng
%A Frank J Palella Jr
%A Holly Wilhalme
%A Jennifer C Price
%A Jordan E Lake
%A Kristine M Erl
%A Larry A Kingsley
%A Lauren E Mellor-Crummey
%A Matthew Budoff
%A Philip M Grant
%A Todd T Brown
%A Wendy S Post
%A son
%J -
%D 2018
%R 10.21767/2575-7733.1000045
%X Background and Aim: Non-alcoholic fatty liver disease (NAFLD) is common among HIV-infected (HIV+) adults. The Liver Fat Score (LFS) is a non-invasive, rapid, inexpensive diagnostic tool that uses routine clinical data and is validated against biopsy in HIV-uninfected (HIV-) persons. CT liver-to-spleen (L/S) attenuation ratio is another validated method to diagnose NAFLD. We compared NAFLD prevalence using the LFS versus L/S ratio among Multicenter AIDS Cohort Study participants to assess the LFS¡¯s performance in HIV+vs. HIV-men.
Methods: In a cross-sectional analysis of men reporting<3 alcoholic drinks daily (308 HIV+, 218 HIV-), Spearman correlations determined relationships between LFS and L/S ratio by HIV serostatus. Multivariable regression determined factors associated with discordance in LFSand L/S ratio-defined NAFLD prevalence.
Results: NAFLD prevalence by LFS and L/S ratio were 28%/15% for HIV+men and 20%/19% for HIV-men, respectively. Correlations between LFS and L/S ratio were weaker among HIV+than HIV-men, but improved with increasing BMI and exclusion of HCV-infected men. LFS and L/S ratio discordance occurred more frequently and across BMI strata among HIV+men, but predominantly at BMI<30 kg/m2 among HIV-men. In multivariate analysis, only lower total testosterone levels were significantly associated with discordance.
Conclusion: NAFLD prevalence was similar by LFS and L/S ratio identification among HIV-men, but dissimilar and with frequent discordance between the two tests among HIV+men. As discordance may be multifactorial, biopsy data are needed to determine the best non-invasive diagnostic test for NAFLD in HIV+persons.
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%K Hepatic steatosis
%K Non-alcoholic steatohepatitis
%K Human immunodeficiency
%K list of open access journals
%K open access
%K open access journals
%K open access publication
%K open access publisher
%K open access publishing
%K open access journal articles
%K imedpub
%K imedpub publishing
%K insight medical publishing
%K imedpub online
%U https://www.imedpub.com/articles/a-comparison-of-the-liver-fat-score-and-ct-livertospleen-ratio-as-predictors-of-fatty-liver-disease-by-hiv-serostatus.php?aid=23412