%0 Journal Article
%T Characteristics, Outcomes and Predictors of Mortality in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt
%A Isaac Kori
%A Jonathan Brill
%A Neta Gotlieb
%A Oren Shibolet
%A Shiri Sherf-Dagan
%J -
%D 2018
%R 10.21767/2575-7733.1000044
%X Background: Transjugular intrahepatic portosystemic shunt (TIPS) is a procedure for hepatic decompression and lowering of portal hypertension. The procedure is performed angiographically by inserting a metal stent between the hepatic and portal vein. Improved techniques and the expanding indications of TIPS throughout the years have made it more common.
Consequently, a better prediction accuracy of its outcomes and complications is warranted. The aims of this study were to present real-life experience with the TIPS procedure and to identify novel risk factors for shortterm complications and mortality.
Methods and findings: We conducted an observational, retrospective study of all patients who underwent a TIPS procedure from 2005-2017 in a single tertiary center. Data collected from the medical records included demographics, anthropometrics, co-morbidities, biochemical tests, indications and short-term (¡Ü 90 days) complications. Binary logistic regression analysis was conducted to determine risk factors for 90-day mortality.
Results: A total of 101 patients (54% males and mean age of 55.9 ¡À 15.7 years) underwent technically successful TIPS insertion. The most common complications were hepatic encephalopathy (43.6%, n=44) and hepatic decompensation (17.8%, n=18). The incidence of 90-day mortality was 21.8% (n=22).
Multivariate analysis revealed that older age (OR=1.061, 95% CI: 1.006-1.119), hypertension (OR=6.193, 95% CI: 1.666-23.024) and high Model for End-Stage Liver Disease (MELD) score (OR=1.167, 95% CI: 1.017-1.329) were independent and significant predictors of early post-TIPS mortality.
Conclusions: Older age, hypertension and high MELD score are independent predictors of early mortality postTIPS. We recommend considering these risk factors when selecting patients for TIPS insertion.
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%K Cirrhosis
%K Portal hypertension
%K TIPS
%K Complications
%K Early mortality
%K Predictors
%K list of open access journals
%K open access
%K open access journals
%K open access publication
%K open access publisher
%K open access publishing
%K open access journal articles
%K imedpub
%K imedpub publishing
%K insight medical publishing
%K imedpub online
%U https://www.imedpub.com/articles/characteristics-outcomes-and-predictors-of-mortality-in-patients-undergoing-transjugular-intrahepatic-portosystemic-shunt.php?aid=23409