%0 Journal Article
%T Interaction between Polyunsaturated Fatty Acids and Genetic Variants in Relation to Breast Cancer Incidence
%A Ahn J
%A Bradshaw PT
%A Crew KD
%A Gammon MD
%A He KA
%A Khankari NK
%A Neugut NI
%A Olshan AF
%A Santella RM
%A Steck SE
%A Teitelbaum SL
%A Terry MB
%J -
%D 2016
%X Higher intake of ¦Ø-3 relative to ¦Ø-6 polyunsaturated fatty acids (PUFAs) may reduce breast carcinogenesis via different metabolic pathways. The PUFA-breast cancer association remains inconclusive, thus, we hypothesized that interactions between the ratio of dietary ¦Ø-3:¦Ø-6 intake and polymorphisms from PUFA-related metabolic pathways would help elucidate an association. Utilizing resources from the Long Island Breast Cancer Study Project, a population-based case-control study (n=1035 cases/1075 controls), we examined interactions between ¦Ø-3:¦Ø-6 ratio and 18 polymorphisms of 15 genes. Compared to the putative lowest risk group (high ¦Ø-3:¦Ø-6, low-risk FASL rs763110 CT/TT genotype), the odds ratio (OR) for breast cancer from unconditional logistic regression models was weakly increased for other exposure-genotype combinations (high ¦Ø-3:¦Ø-6, high-risk FASL CC genotype, OR=1.18, 95% confidence interval (CI)=0.90, 1.53; low ¦Ø-3:¦Ø-6, CT/TT genotype, OR=1.35, 95% CI=1.09, 1.66); but was approximately null for the putative highest risk group (low ¦Ø-3:¦Ø-6, CC genotype; OR=1.06, 95% CI=0.81, 1.38). We observed an interaction between the ¦Ø-3:¦Ø-6 ratio and FASL rs763110 on the additive scale [Relative Excess Risk Due to Interaction (RERI)=-0.47, 95% CI=- 0.92, -0.02]. Interactions with other polymorphisms considered were not evident. Our findings suggest that the PUFA-breast cancer association may be modified by FASL. However, additional research is needed given this interaction may be due to chance and is inconsistent with our a priori biologic hypothesis.
%K Breast cancer
%K Epidemiology
%K Fat/omega-3
%K Omega-6/fish oil
%K Single nucleotide polymorphisms
%K list of open access journals
%K open access
%K open access journals
%K open access publication
%K open access publisher
%K open access publishing
%K open access journal articles
%K imedpub
%K imedpub publishing
%K insight medical publishing
%K imedpub online
%U https://www.imedpub.com/articles/interaction-between-polyunsaturated-fatty-acids-and-genetic-variants-in-relation-to-breast-cancer-incidence.php?aid=18160