%0 Journal Article
%T New Antitumoral Pharmacological Strategies Involving Ca2+/Camp Signaling Pathways
%A Afonso Caricati-Neto
%A Alberto Andrade Leite
%A Le
%A Menezes-Rodrigues FS
%A Ruggero Errante P
%A ro Bueno Bergantin
%J -
%D 2017
%X Cell signaling is a crucial event for the survival and progress of normal cellular functions. However, mutations of certain genes can lead to the emerging of cancer cells, which can use these signaling mechanisms for their survival, growth and dissemination. Among these mechanisms, we highlight the role of cyclic nucleotides 	such as cAMP, and Ca2+ and its Ca2+ channels, which are functionally altered, or amplified, in different types of cancer cells. Understanding these mechanisms is crucial for knowledge of process of tumor progression, and for the creation of new pharmacological strategies to control the growth and spread of tumor cells. In this review, we address the relevance of cyclic nucleotides such as cAMP, 	and Ca2+ channels in tumor cells, emphasizing the possibility of combined pharmacological interventions which interfere with these intracellular signaling 	pathways.
%K Cancer
%K Ca2+ channels
%K Ca2+ signaling
%K Cyclic adenosine monophosphate
%K cAMP signaling
%K list of open access journals
%K open access
%K open access journals
%K open access publication
%K open access publisher
%K open access publishing
%K open access journal articles
%K imedpub
%K imedpub publishing
%K insight medical publishing
%K imedpub online
%U https://www.imedpub.com/articles/new-antitumoral-pharmacological-strategies-involving-ca2camp-signaling-pathways.php?aid=19261