%0 Journal Article
%T IL-17A/IL-17F Double KO Mice Are Resistant to Lipopolysaccharide Induced Endotoxic Shock
%A Anwarul Haque
%A Chiaki Kajiwara
%A Tetsuya Matsumoto
%A Yoshikazu Ishii
%J -
%D 2017
%R 10.21767/2248-9215.100014
%X Aim: IL-17 family members, IL-17A and -17F are   pro-inflammatory cytokines important for host immune modulation in   infection and inflammatory diseases conditions. IL-17A has been shown   playing a critical role in defense against bacterial infections and   IL-17AF deficient mice (DKO) reported less protective. However, the role   of IL-17 in endotoxic shock is largely undefined.
Materials and Methods: Wild and DKO mice were   intraperitoneally lipopolysaccharide (LPS) administered and their   survival status was recorded. Neutrophil, -T cells in peritoneal   fluids and pro- and anti-inflammatory cytokines, chemokines in serum in   endotoxic wild and DKO mice were evaluated.
Results: In this study, we observed a higher   mortality rate in wild than DKO, in intraperitoneal LPS induced shock.   Mortality was observed in correlation with increased pro-inflammatory   cytokines and chemokines. We also observed a significant rise of -T   cells in peritoneal cavity by LPS in wild, which is known to be a most   potent source for IL-17 release and neutrophil recruitment at the site   of infection. Neutrophil recruitment was shown as a protective   phenomenon in murine in bacterial infection, but the same phenomenon was   not observed in LPS induced sepsis.
Conclusions: These findings suggest that neutrophil   recruitment at infection site may be beneficial in case of direct   bacterial exposure, but not in endotoxin exposure to host tissue. This   study shades a comprehensive understanding of IL-17A/F functions in   acute peritonitis followed by endotoxic shock that could be beneficial   for selection of infection for IL-17 directed therapy
%K Anwarul Haque
%K Chiaki Kajiwara
%K Tetsuya Matsumoto
%K Yoshikazu Ishii and Kazuhiro Tateda
%K IL-17A
%K IL-17F
%K Endotoxic shock
%K Neutrophils
%K £¿£¿-T cells
%K Cytokines
%U https://www.imedpub.com/abstract/il17ail17f-double-ko-mice-are-resistant-to-lipopolysaccharide-induced-endotoxic-shock-19096.html