%0 Journal Article
%T Ultrasound Promoted Synthesis and Antimicrobial Evaluation of Novel Seven and Eight-Membered 1,3-Disubstituted Cyclic Amidinium Salts
%A Mar¨ªa M. Blanco
%A Mar¨ªa A. Ream¨ªrez
%A Mar¨ªa C. Caterina
%A Isabel A. Perillo
%A Guido A. Oppezzo
%A Mar¨ªa S. Shmidt
%A Gabriel O. Gutkind
%A Jos¨¦ Di Conza
%A Alejandra Salerno
%J Open Journal of Medicinal Chemistry
%P 139-152
%@ 2164-313X
%D 2020
%I Scientific Research Publishing
%R 10.4236/ojmc.2020.104008
%X <div style=\"text-align:justify;\">
	Series of 1,3-dibenzyl-1<i>H</i>-4,5,6,7-tetrahydro-1,3-diazepinium
and 1,4,5,6,7,8-hexahydro-1,3-diazocinium salts derivatives were efficiently
synthesized in excellent yields by dehydrogenation of the corresponding <i>N</i>,<i>N</i><i>'</i><span \"=\"\">-dibenzyl aminals employing <i>N</i>-bromosuccinimide
(NBS) as dehydrogenating agent under ultrasound irradiation. The present
methodology has proven to be simple, efficient and environmentally benign. All
novel compounds were identified and characterized by <sup>1</sup>H and <sup>13</sup>C
NMR spectra. The synthesized compounds were screened for their antimicrobial
activities.</span> 
</div>
%K Medium Ring Amidinium Salts
%K Ultrasonic Assisted Synthesis
%K Antimicrobial
%K Green Chemistry
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=106129