%0 Journal Article
%T Long Term Benefit of Autologous Bone Marrow Stem Cell Transplantation without Immunosuppression in Chronic  Type 1 Diabetic Patients
%A Alejandro Mesples
%A Yun Zhang
%A Xiang Hu
%J Stem Cell Discovery
%P 1-14
%@ 2161-6787
%D 2020
%I Scientific Research Publishing
%R 10.4236/scd.2020.101001
%X <b>Background</b>:Autologous bone marrow stem cell transplantation
without immune suppression has been proposed as a safe and efficient therapeutic option to replace <i>¦Â</i>-cell
mass destroyed by specific antibodies in chronic type 1 diabetes but we have
not scientific information about how long the metabolic stability is
maintained. <b>Material and Method</b>: From 2010 to 2014, were included 134 chronic type 1
diabetics patients (p.) in an autologous bone marrow stem cell transplantation
protocol, stimulated with filgrastim, without immune suppression, c peptide
&lt; 0.5 ng/ml and pancreatic antibodies negatives, without diabetes
complications. 65 Female and 69 Male patients, with 36 + 20 years old and
insulin-dependent were treated. Follow up variables, c peptide, A1C, pancreatic
islets and GAD antibodies and insulin dose at 6, 12, 24 and 36 months were
performed. <b>Results</b>:C peptide, 6 months after transplantation more than 0.9 ng/ml in 61
patients (45%) (P = 0.001, CI = 95%). At 12 months 50 patients (37%) (P =
0.001, CI = 95%). At 24 months 53 patients (39%) (P = 0.001, CI = 95%). At 36
months 51 patients (38%) (P = 0.001, CI = 95%). A1C before transplant, &lt;7%
was observed in 25 p. (18%). At 6 months 68 p. (50%), 12 months 90 p. (67%), 24
months 92 p. (68%), at 36 months in 85 p. (63%) Patients without Insulin dose,
at 6 months 61 p. (45%), 12 months 60 p. (44%), 24 months 58 p. (43%), at 36
months in 53 p. (39%). No evidence of new pancreatic antibodies or adverse
events. <b>Conclusion</b>:Autologous bone marrow stem cell transplantation, without immunosuppression,
improves pancreatic function and metabolic control without new immune reaction
after three years of follow up in chronic type 1 diabetic patients.
%K Type 1 Diabetes
%K Bone Marrow Transplantation
%K Bone Marrow Stem Cells
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=105770