%0 Journal Article
%T Studies on Parkinson¡¯s-Disease-Linked Genes, Brain Urea Levels and Histopathology in Rotenone Induced Parkinson¡¯s Disease Rat Model
%A Suchitra Kavuri
%A Senthilkumar Sivanesan
%A Mathew D. Howell
%A Rajagopalan Vijayaraghavan
%A Jayakumar Rajadas
%J World Journal of Neuroscience
%P 216-234
%@ 2162-2019
%D 2020
%I Scientific Research Publishing
%R 10.4236/wjns.2020.104021
%X Parkinson¡¯s disease (PD) is a debilitating neurological disorder that
affects <span>the aged population globally. This
study aimed to explore how oral- and in</span>traperitoneal-rotenone-induced PD
alters brain urea levels, histopathology, and key Parkinsonism<span>-related genes in the striatum. Hematoxylin and
eosin staining was performed for histopathology assessment and real-time
polymerase chain reaction was performed for gene expression. Rotenone 3 mg/kg
body weight (Rot-3-ip) for 21 days and rotenone 50 mg/kg body weight
(Rot-50-po) for 28 days significantly (p &lt; 0.05) altered alpha-synuclein and
tyrosine hydroxylase protein expression and <i>Snca</i>, <i>Becn</i>1 and <i>Prkaa</i>1 gene expression in the striatum. Lewy bodies were visible in
both Rot-3-ip and Rot-50-po rat brains. There were </span><span>contrasting features in brain and liver
histopathology between the oral and</span><span> intraperitoneal rotenone treatment groups. However, there was no significant (p
&lt; 0.05) difference in the brain urea levels between intraperitoneal and oral
rotenone treatment groups. The propagation of PD through oral and
intraperitoneal rotenone</span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span><span><span style=\"font-family:&quot;\">can have different impacts on the pathological sequence of events based
on the molecular approach.
%K Parkinson¡¯s Disease
%K Rotenone Intraperitoneal and Oral
%K Brain Urea
%K Al-pha-Synuclein
%K Beclin-1
%K AMP-Activated Protein Kinase
%K Brain and Liver Pa-thology
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=104471