%0 Journal Article
%T Effect of a Diet Rich in Interesterified, Non-Interesterified and Trans Fats on Biochemical Parameters and Oxidative Status of Balb-c Mice
%A Elinete Eliete de Lima
%A Luiza S. E. P. W. Castro
%A Valdel¨˛cia Maria A. de S. Grinevicius
%A Josiane Hilbig
%A N¨˘dia S. R. S. Mota
%A Rodrigo C. Zeferino
%A Roberta C. da Silva
%A Iv¨˘n Jachmani¨˘n
%A Edson Luiz da Silva
%A Rozangela C. Pedrosa
%A Jane Mara Block
%J Food and Nutrition Sciences
%P 1032-1052
%@ 2157-9458
%D 2020
%I Scientific Research Publishing
%R 10.4236/fns.2020.1111073
%X The
aim of this study was to investigate the effects of different modified fats on the body weight,
biochemical profile, and biomarkers of hepatic oxidative status in Balb-<i>c</i> mice. The animals
were divided into four groups and fed for 75 days with a normolipidic (Control Group, CG) or hiperlipidic diets (40% kcal) containing
a commercial interesterified fat (IFG) rich in palmitic acid (39%); a blend of
non-interesterified fat (NIFG), with 2-fold less saturated fatty acids at the <i>sn</i>-2 position of
triacylglycerols; or a partially hydrogenated
vegetable oil (PHFG), source of trans fatty
acid (20%) and of linolenic acid (6%). The mice of the IFG and NIFG presented
similar results in all evaluated parameters. The serum biochemical profile and
hepatic oxidative stress markers in mice of the PHFG were similar to CG, except
for total cholesterol (TC) which was significantly higher (p < 0.05) for the
mice of the PHFG. The mice feed with interesterified fat (IFG) showed
serum TC (p < 0.01), non-HDL-C (p < 0.05), glucose (p < 0.05) and
hepatic reduced glutathione values (2.7 fold, p < 0.05) and glutathione
reductase activity (2.4 fold, p < 0.001) significantly higher when compared
to the mice fed with partially
hydrogenated vegetable oil (PHFG). The hydrogenated fat source of trans fatty
acid (20%) had less important metabolic effects than fats containing