%0 Journal Article %T Perspectives in solubility measurement and interpretation %A Avdeef %A Alex %A Bergstr£¿m %A Christel A.S. %J - %D 2019 %R 10.5599/admet.686 %X Sa£¿etak Several key topics in solubility measurement and interpretation are briefly summarized and illustrated with case studies drawing on published solubility determinations as a function of pH. Featured are examples of ionizable molecules that exhibit solubility-pH curve distortion from that predicted by the traditionally used Henderson-Hasselbalch equation and possible interpretations for these distortions are provided. The scope is not exhaustive; rather it is focused on detailed descriptions of a few cases. Topics discussed are limitations of kinetic solubility, ¡®brick-dust and grease-balls,¡¯ applications of simulated and human intestinal fluids, supersaturation and the relevance of pre-nucleation clusters and sub-micellar aggregates in the formation of solids, drug-buffer/excipient complexation, hydrotropic solubilization, acid-base ¡®supersolubilization,¡¯ cocrystal route to supersaturation, as well as data quality assessment and solubility prediction. The goal is to highlight principles of solution equilibria ¨C graphically more than mathematically ¨C that could invite better assay design, to result in improved quality of measurements, and to impart a deeper understanding of the underlying solution chemistry in suspensions of drug solids. The value of solid state characterizations is stressed but not covered explicitly in this mini-review %K Solubility-pH %K shake-flask solubility %K intrinsic solubility %K thermodynamic solubility %K Henderson-Hasselbalch equation %K supersaturation %K pre-nucleation clusters %K drug aggregates %K drug salts %K pharmaceutical cocrystals %U https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=319231