%0 Journal Article
%T 4-Amino- and 4-Hydroxycyclohexane-1,1-dicarboxylic Acid Peptides
%A Makarevi£¿
%A J.
%A £¿kari£¿
%A V.
%J -
%D 1981
%X Sa£¿etak 4-Amino-, 4-oxo-, and 4-hydroxy-cyclohexane-1 ,1-dicarboxylic acids have been inserted into di- and tri-peptides containing glycine, L-phenylalanine, L-cyclohexylalanine, and L-tyrosine. The geometries of 4-c-(IX A) and 4-t-(IX B) benzamidocyclohexane- r-1-carboxy-1-carbonyl-L-phenylalanine methyl esters and 4-c- -(XXIII A) and 4-t-(XXIII B) benzoxycyclohexane-r-1 -carbomethoxy- 1-carbonyl-L-cyclohexylalanine methyl esters were confirmed by their NMR spectra and intramolecular cyclisations of the cis isomers. The ring opening of 2-oxabicyclo[2.2.2]octan-3-one- 4-carbonyl-L-cyclohexylalanine methyl ester (XXIV) in methanolic hydrochloric acid afforded 4-c-hydroxycyclohexane-r- 1- -carbomethoxy-1-carbonyl-L-cyclohexylalanine methyl ester (XXI A) which on benzoylation was converted into the product identical with the isomer (XXIII A)
%U https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=286572