%0 Journal Article
%T The absorption of oral morroniside in rats: In vivo, in situ and in vitro studies
%A LI
%A JINGLAI
%A MU
%A YANLING
%A XIONG
%A SHAN
%A ZHANG
%A ZHENQING
%J -
%D 2019
%R 10.2478/acph-2019-0012
%X Saˋetak Morroniside is one of the most important iridoid glycosides from Cornus officinalis Sieb. et Zucc. In the present study, the pharmacokinetics and bioavailability studies of morroniside were conducted on Sprague-Dawley (SD) rats. A rat in situ intestinal perfusion model was used to characterize the absorption of morroniside. Caco-2 cells were used to examine the transport mechanisms of morroniside. The pharmacokinetic study of morroniside exhibited linear dose-proportional pharmacokinetic characteristics and low bioavailability (4.3 %) in SD rats. Its average Peff value for transport across the small intestinal segments changed from (3.09 ㊣ 2.03) ℅ 10每6 to (4.53 ㊣ 0.94) ℅ 10每6 cm s每1. In Caco-2 cells, the Papp values ranged from (1.61 ㊣ 0.53) ℅ 10每9 to (1.19 ㊣ 0.22) ℅ 10每7 cm s每1 for the apical to basolateral side and the Pratio values at three concentrations were all lower than 1.16. Morroniside showed poor absorption and it might not be a specific substrate of P-glycoprotein (P-gp)
%K morroniside
%K pharmacokinetics
%K absorption
%K rats
%K in situ single-pass intestinal perfusion
%K Caco-2 cell
%U https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=305144