%0 Journal Article
%T Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways
%A CUI
%A YUXIN
%A FAN
%A MENGYING
%A LIU
%A RUI
%A WANG
%A BO
%A YU
%A RUNZE
%A ZHANG
%A YANMIN
%J -
%D 2019
%R 10.2478/acph-2019-0021
%X Sa£¿etak The aim of this study was to investigate the inhibitory effect of TAD1822-7, a synthesized taspine derivative, on cancer through its effects on tumor cell growth and angiogenesis via suppression of EphrinB2. The obtained data showed that TAD1822-7 decreased Bel-7402 cell viability and colony formation ability and suppressed cell migration. TAD1822-7 effectively inhibited blood vessel formation in an aortic ring assay to examine angiogenesis. Moreover, it also downregulated the expression of VEGFR2, VEGFR3, CD34, PLC¦Ã, Akt, MMP2, MMP9, and CXCR4, and suppressed the expression of EphrinB2 and its PDZ protein, PICK1, in Bel-7402 cells. These results indicate that TAD1822-7 is a potential anti-angiogenic agent that can inhibit the viability and migration of Bel-7402 cells via suppression of EphrinB2 and the related signaling pathways
%K TAD1822-7
%K EphrinB2
%K Bel-7402 cells
%K proliferation
%K migration
%K anti-angiogenesis
%U https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=315406