%0 Journal Article
%T Phenolic compounds of Iris adriatica and their antimycobacterial 
effects
%A ALPERTH
%A FABIAN
%A BUCAR
%A FRANZ
%A DUKA
%A IVAN
%A FERREIRA MOUR£¿O
%A MARIA
%A HRU£¿EVAR
%A DARIO
%A KUNERT
%A OLAF
%A MALE£¿
%A £¿ELJAN
%A MAYER
%A STEFANIE
%A MITI£¿
%A BO£¿ENA
%A OCHENSBERGER
%A SANDRA
%A SKALICKA-WO£¿NIAK
%A KRYSTYNA
%A TUREK
%A IVANA
%A VLAD LUCA
%A SIMON
%J -
%D 2019
%R 10.2478/acph-2020-0037
%X Sa£¿etak Little is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant en-demic to Dalmatia (Croatia). For this purpose, we performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using Mycobacterium smegmatis mc2 155. One obtained fraction was found to be antimyco-bacterially active with a MIC of 64 mg L-1. Furthermore, fractions were tested for resistance modulatory effects using ethidium bromide as substrate. We were able to identify the pure isoflavonic compounds irigenin and irilone and a fraction containing mainly the benzophenone 2,4,6-trihydroxy-4-methoxy-benzophenone to be responsible for the resistance-modulatory activity of this plant
%K Iris adriatica
%K Radix Iridis
%K phenolic compounds
%K Mycobacterium smegmatis
%K re-sistance modulation
%K ethidium bromide
%K MIC
%U https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=322479