%0 Journal Article
%T Therapeutic bullfrog oil-based nanoemulsion for oral application: Development, characterization and stability
%A AMARAL-MACHADO
%A LUCAS
%A DE SOUZA ARAUJO
%A ADRIANO ANTUNES
%A DO NASCIMENTO ALENCAR
%A EVERTON
%A GENRE
%A JULIETA
%A ROCHELLE DO VALE MORAIS
%A ANDREZA
%A RUTCKEVISKI
%A RENATA
%A TABOSA DO EGITO
%A ERYVALDO SOCRATES
%A XAVIER-JR
%A FRANCISCO HUMBERTO
%J -
%D 2019
%R 10.2478/acph-2019-0001
%X Sa£¿etak The aim of this study was to develop, optimize, and characterize a stable therapeutic bullfrog oil based nanoemulsion for oral application using a rational experimental design approach. The optimized oral nanoemulsion contained 0.2 % sodium benzoate and 0.02 % propyl-paraben as preservatives; 0.1 % sucralose and 0.4 % acesulfam K as sweeteners and 0.1 % tutti-frutti as flavoring to mask the unpleasant organoleptic characteristics of bullfrog oil. The oral O/W-nanoemulsion showed the droplet size, PDI, zeta potential, and pH of 410 ¡À 8nm, 0.20 ¡À 0.02, ¨C38 ¡À 2.5 mV, and 6.43 ¡À 0.05, respectively. The optimized oral nanoemulsion showed a milky single-phase and optimal physical stability at 25 ¡ãC for 90 days. Indeed, higher oxidation induction time and lower formation of peroxides in the oral nanoemulsion were responsible for improving its stability. A therapeutic delivery system containing bullfrog oil for oral application was successfully developed and optimized with ideal thermo-oxidative stability
%K bullfrog oil
%K nanoemulsion
%K thermo-oxidative stability
%K experimental design
%K oral application
%K therapeutic nanosystem
%U https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=299893