%0 Journal Article %T Physiologically based pharmacokinetic (PBPK) modeling and simulation in drug discovery and development %A Khan %A Ansar Ali %A Shaik %A Abdul Naveed %J - %D 2019 %R 10.5599/admet.667 %X Sa£żetak Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic or physiology based mathematical modeling technique which integrates the knowledge from both drug-based properties including physiochemical and biopharmaceutical properties and system based or physiological properties to generate a model for predicting the absorption, distribution, metabolism and excretion (ADME) of a drug as well as pharmacokinetic behavior of a drug in preclinical species and humans %K Physiologically based pharmacokinetic modeling %K PBPK %U https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=317229