%0 Journal Article
%T Vasoactive stress hormone (adrenaline, noradrenaline and cortisol) concentration in plasma after administration of low doses of S-(+)-ketamine epidurally
%A ELVE£¿I-GA£¿PAROVI£¿
%A VESNA
%A IGNJATI£¿ ZOKI£¿
%A TATJANA
%A MIHALJEVI£¿
%A LJILJANA
%A MIHALJEVI£¿
%A SLOBODAN
%A ORE£¿KOVI£¿
%A SLAVKO
%A £¿A£¿I£¿
%A MARKO
%J -
%D 2009
%X Sa£¿etak Background and Purposes: The aim of this study was to investigate the effect of epidurally administered S-(+)-ketamine on vasoactive stress hormones. It was a prospective study conducted after approval of the Ethical Committee and informed consent of patients. Materials and Methods: The study was performed on 80 patients: 40 patients in Group 1 (0.5% bupivacaine) and 40 patients in Group 2 (0.5% bupivacaine + 25 mg S-(+)-ketamine ¨C 0.326 mg/kg-bm). All patients were adults aged between 18 and 45 years, ASA I and II with epidural anaesthesia for a surgical procedure. Vasoactive parameters: concentrations of adrenaline, noradrenaline and cortisol were measured 30 minutes before setting the vein pathway and 17¨C25 min. after application of anaesthetics. Results: There were no statistically significant changes in vasoactive stress hormones (adrenaline, noradrenaline and cortisol) plasma concentrations after administering 0.5% bupivacaine, 0.5% bupivacaine + S-(+)- -ketamine epidurally. Conclusion: Setting central nervous block before skin incision, using local anaesthetic, and S-(+)-ketamine, leaves concentrations of stress hormones in plasma within referent values. Adding a low dose of S-(+)- -ketamine into the epidural space in combination with 0.5% bupivacaine does not have an effect on the concentration of stress hormones in plasma
%K S-(+)-ketamine
%K epidural anaesthesia
%K vasoactive hormones
%U https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=60105