%0 Journal Article
%T Neurochemical and Behavioural Changes in Rat Models of Depression
%A Diksic
%A Mirko
%A Kova£¿evi£¿
%A Tomislav
%A Skelin
%A Ivan
%J -
%D 2011
%R 10.5562/cca1817
%X Sa£¿etak Depression is one of the most prevalent psychiatric disorders with significant lifetime prevalence. The study of human depression is hindered by the relatively significant heterogeneity of this disorder. As a result of these heterogeneities, studies using a sound and representative animal model of depression are extremely valuable and, in general, provide important information regarding the neurochemical/ biological changes occurring during depression and the subsequent treatment of its symptoms. In this review we concentrate on two solid rat models of depression: olfactory bulbectomized (OBX) rats and Flinders Sensitive Line (FSL) of rats. These two models were selected because they possess all three characteristics of a good animal model; face, predictive and constructive validities. We also emphasize the brain serotonergic system and we discuss the open field and forced swim test to assess behaviour. (doi: 10.5562/cca1817
%K depression
%K olfactory bulbectomized rat model of depression
%K Flinders sensitive line rat
%K Flinders Resistant line rat
%K animal model of depression
%U https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=107227