%0 Journal Article %T Neurochemical and Behavioural Changes in Rat Models of Depression %A Diksic %A Mirko %A Kova£¿evi£¿ %A Tomislav %A Skelin %A Ivan %J - %D 2011 %R 10.5562/cca1817 %X Sa£¿etak Depression is one of the most prevalent psychiatric disorders with significant lifetime prevalence. The study of human depression is hindered by the relatively significant heterogeneity of this disorder. As a result of these heterogeneities, studies using a sound and representative animal model of depression are extremely valuable and, in general, provide important information regarding the neurochemical/ biological changes occurring during depression and the subsequent treatment of its symptoms. In this review we concentrate on two solid rat models of depression: olfactory bulbectomized (OBX) rats and Flinders Sensitive Line (FSL) of rats. These two models were selected because they possess all three characteristics of a good animal model; face, predictive and constructive validities. We also emphasize the brain serotonergic system and we discuss the open field and forced swim test to assess behaviour. (doi: 10.5562/cca1817 %K depression %K olfactory bulbectomized rat model of depression %K Flinders sensitive line rat %K Flinders Resistant line rat %K animal model of depression %U https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=107227